paperKB
coga / coga-kb
Help
Sign in

Chunk #14 — RESULTS — Creating and validating a latent externalizing factor in MVP

Source
A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.
Embedded
yes

Text

Next, we performed multivariate GWASs within the EUR-like and AFR-like veterans, separately, followed by an inverse-variance weighted fixed effects meta-analysis in METAL60. There were 155 independent genome wide significant loci in the meta-analysis, of which only 11 were significant Q-SNPs (p <.05/155 = 3.23 x10−4). Of the 138 of these loci that were present in EXT1.0, 94.2% (95% CI = 88.9%, 97.5%) were sign concordant and 116 (84.1%) of the loci were nominally significant (p < .05).