without changing any anxiety measures (Zarrindast et al., 2008). In addition to these studies on unconditioned fear, the expression of conditioned fear is also modulated by eCB signaling in the CeA. Specifically, post-training infusion of the CB1 antagonist SR141716 into the CeA causes impairment within session (short-term) extinction of conditioned freezing responses to CS+ presentation (Kamprath et al., 2011). Taken together these data suggest that eCB signaling in the CeA serves to facilitate active/exploratory behaviors, and suppress passive/freezing coping responses to salient aversive stimuli.
