With regard to motivational behavior, intra-CeA administration of the CB1 antagonist, AM251, produced place aversion and blocked the place preference induced by morphine (Rezayof et al., 2011). In contrast, activation of CB1 receptors with ACPA produced place preference when administered alone and enhanced place preference induced by morphine (Rezayof et al., 2011). One limitation of these studies is the lack of distinction between the CeAL and CeAM; due to the close proximity of these nuclei, it will be challenging to dissociate functional roles of these regions using microinjection techniques.
