Chunk #25 — Results — FTO×PA Interaction and Obesity Traits — FTO×PA interaction and BMI

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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

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While we observed a strong effect of the FTO risk allele on BMI in children and adolescents (Table S3), this effect was not modified by their PA level (p interaction = 0.98) (Figure 3). There was no heterogeneity between the studies (I 2 = 1%).