In order to address the question of whether or not marijuana use predicted brain activation above and beyond alcohol use, we completed both whole brain and ROI regression analyses for number of alcoholic drinks over the past 30 days and BOLD activation for each condition. Whole brain analyses did not reveal any significant relationship between alcohol use and BOLD activity for either the masked angry or masked happy condition, and results from the amygdalar ROI analyses also revealed no significant relationship between alcohol use and BOLD activation for either condition. Results from the cingulate gyrus (CG) ROI analyses revealed a small area of association between alcohol use in the last 30 days and BOLD activity during masked angry faces, which was in a more anterior and superiorly placed region within the cingulate than the pattern detected for the relationship between MJ use and BOLD activity, which is illustrated in Figure 5a. For the masked happy condition, an association between number of drinks and BOLD activity was detected for mid and posterior cingulate, however, no area of the cingulate gyrus was
