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Chunk #45 — ONLINE METHODS — Expression analysis

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Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
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to the gene expression signal. To prevent spurious associations due to confounding by nearby eQTLs, we corrected the model for the most strongly associated eQTL SNP in the region. For the tumor analysis only, we also added the copy number of the candidate gene as a covariate because apparent associations between germline genotype and tumor expression may be confounded or obscured by somatic copy number alterations.