LCU-PGS was higher in BIP patients with psychotic experience than those without (P=0.02). We applied single- and multi- PGS analyses to predict BIP with psychotic experience, and BIP without psychotic experience from controls, separately. Single-PGS analyses revealed LCU- and CUD- PGSs predicted BIP with psychotic experience but not BIP without psychotic experience (Figure 4C). Multi-PGS models demonstrated significant improvement for BIP with psychotic experience (fold change R2=1.17, PFDR=7.72E-04) but not for those without. Details are provided in Supplementary Tables 18–21.
