TOP participants exhibited much larger proportions of cannabis users with BIP and SCZ compared to controls (Supplementary Table 1). Therefore, we performed sensitivity analyses using participants without recent cannabis use, which showed the prediction efficiency of LCU- and CUD- PGSs remained significant in single-PGS models (Supplementary Table 15). Multi-PGS models demonstrated continued improvement in prediction for BIP (fold change R2=1.13, PFDR=0.04) but not for SCZ (fold change R2=1.03, PFDR=0.20; Supplementary Tables 16–17).
