In single-PGS models, both LCU- and CUD- PGSs significantly predicted SCZ diagnosis (Figure 4A and Supplementary Table 15). A similar result was found for BIP where LCU- and CUD- PGSs predicted diagnosis (Figure 4B). As a comparator, the NMSC-PGS predicted neither SCZ nor BIP diagnoses. For SCZ and BIP, multi-PGS models including LCU- and CUD- PGSs showed a small yet significant improvement in explained variance beyond the psychotic-specific single-PGS models (Figure 4 and Supplementary Tables 16–17). Those improvements by LCU- and CUD- PGSs remained significant after including both psychotic disorders’ PGS in multi-PGS models (Supplementary Tables 16–17). Notably, adding NMSC-PGS did not show significant improvement.
