We examined the association between polygenic risk score for schizophrenia, as defined using varying p-value cutoffs (pT) for any substance use disorder (i.e., having tobacco, alcohol, cannabis or stimulant use disorder, as defined above), and then for each specific substance: tobacco use disorder, alcohol use disorder, cannabis use disorder, and stimulant use disorder. Figure 2 shows the association between the schizophrenia polygenic risk scores and these phenotypes in each individual dataset and then as a mega-analysis.
