The phenotype most strongly and consistently associated with schizophrenia polygenic risk scores was the “any substance use disorder” phenotype. In general, the associations became stronger overall with less restrictive p-value cutoffs, which is consistent with previous studies (22, 23). In the mega-analysis, the association between any substance use disorder and schizophrenia polygenic risk score peaked at pT<0.5; pseudo R2 range 0.8% to 3.7%, minimum p = 4×10−23.
