Activation of JNK, increased IR, and impaired GT in WT-FHDA,B) Whole liver lysates were used to evaluate the levels of P-JNK (top) and JNK (bottom) by immunoblot analyses. C,D) IR was evaluated by injecting insulin (ip, 0.75 U/kg; Eli Lilly), while GT was determined by injecting glucose (ip, 2 g/kg) into each mouse fasted for 6 hours. Tail blood from each mouse was collected at indicated times following insulin or glucose injection. Each point represents the average value (C–F). *Significantly different from the corresponding time-course groups.
