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Chunk #3 — Methods and Materials — Subject Recruitment — Virginia Twin Study of Psychiatric and Substance Use Disorders

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The AVPR1A gene and substance use disorders: association, replication, and functional evidence.
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The Virginia Twin Study of Psychiatric and Substance Use Disorders (VATSPSUD) was ascertained through the Mid-Atlantic Twin Registry at Virginia Commonwealth University with minimal inclusion criteria: birth in the Commonwealth of Virginia within the target age cohort. In this data set, we focus on 2231 self-identified European-American male subjects. Drug use disorder is operationalized as lifetime dependence on any illicit substance (9.68%). Previous work in this sample has demonstrated a satisfactory genomic inflation factor of .99 (20).