A GWAS for anxiety disorders was conducted in the FinnGen22 release 6 sample consisting of 7,671 cases with a generalized anxiety disorder (ICD-10: F41.1, ICD-9: 3000C, ICD-8: 300,00), panic disorder (ICD-10: F41.0; ICD-9: 3000B, 3002B) or phobic anxiety (ICD-10: F40, ICD-9: 3002C, 3002D, 3002X) diagnoses and 161,438 controls without a history of any psychiatric diagnoses (ICD-10: F00-F99, ICD-9: 290-319, ICD-8: 290-315). With ICD-9 codes the first three digits signify numerical value (e.g., the code 3002B is included in the code range 290-319). Cases with psychotic disorders (ICD-10: F2; ICD-9: 295, 297, 298; ICD-8: 295, 297, 298), autism spectrum disorders (ICD-10: F84.0, F84.1, F84.5; ICD-9: 2990; ICD-8: 299,99) or intellectual disability (ICD-10: F7, ICD-9: 317-319; ICD-8: 311-315) were excluded. Additionally, the age range of controls was adjusted to match to that of cases and a more stringent filtering on imputation info score was used for the anxiety GWAS (INFO>0.8). This GWAS of core anxiety in the FinnGen22 cohort was meta-analyzed with a GWAS of self-report of physician diagnosis of anxiety in the MVP112, with the purpose of generating weights for an ANX-PRS (see below).
