We conducted a cross-ancestry meta-analysis of ASSET-derived (to maintain analytic consistency) European and African ancestry addiction-rf summary statistics. First, SNPs with evidence of SUD pleiotropy (i.e., effects on 2 SUDs, 3 SUDs, or all 4 SUDs, including different sets of SUDs in each ancestry) in both ancestral groups were extracted. SNPs with evidence of cross-ancestral heterogeneity (i.e., Cochran’s Q statistic <5e-8) were removed, leaving 317,447 SNPs. A meta-analysis in METASOFT55 using a random-effects meta-analysis with ancestry group as a random effect was used to identify cross-ancestral effects. We report the random effects BETA and p-value as cross-ancestry effects.
