ASSET does not leverage the genetic correlation to identify variants of interest (as GenomicSEM does); instead, subset searches scaffold effects into pleiotropic and non-pleiotropic variants based on effect size and standard error derivations that estimate the degree to which the SNP-trait association is due to pooled effects across the phenotypes, vs. a single phenotype driving variant association. Loci were designated as substance-specific when they were only significantly associated with only 1 SUD. As ASSET does not automatically account for sample overlap; we used LDSC-estimated genetic correlations to adjust for overlap within the European ancestry ASSET covariance term.
