We targeted our search to four a priori defined medial prefrontal cortex (PFC) regions of interest (ROIs), as previously derived (see Kareken et al., 2010b; Figure 3). These comprised right and left medial prefrontal (mPFC), and right and left ventromedial prefrontal (vmPFC) areas. All PFC ROIs have rostro-caudal extents spanning +56 mm to +36 mm in MNI space. The mPFC has a superior extent of +14 mm and an inferior extent of −6 mm, while vmPFC spans −6 mm to −22 mm. The MarsBar utility (Brett et al., 2002; http://marsbar.sourceforge.net/) was used to extract each subject’s mean AcO and AppCo activation value as contrasted with the odorless control for each ROI. We hypothesized that (1) there would be increased activation to AcO in these ROIs, (2) mood condition would interact with the activation, (3) self-reported negative and positive urgency would be positively associated with this AcO-induced activation, and (4) urgency and AcO activation would be associated with self-reported subjective craving and problematic alcohol use.
