These have been compared with their counterpart lines bred for low drinking (NP, LAD-1, LAD-2, ANA sNP, UChA) on a number of behaviors. We reason that if several of these pairs of rat lines differ consistently on a behavioral response to alcohol in the direction predicted by the work of the Schuckit group, this would suggest substantial genetic correlation of that trait with drinking. There are also rat lines bred for high (HARF) vs low (LARF) alcohol preference drinking during a limited access test (Le et al. 2001), and high (HAP-1, HAP-2) and low (LAP-1, LAP-2) preference drinking mouse lines (Grahame et al. 1999). Mouse lines selectively bred for severe (Withdrawal Seizure-Prone, WSP-1 and WSP-2) versus mild (Withdrawal Seizure-Resistant, WSR-1 and WSR-2) withdrawal handling induced convulsions after chronic alcohol vapor inhalation have provided some relevant data (Crabbe 1996). Other pairs of mouse lines selected for alcohol-related traits [e.g., FAST/SLOW, HAW/LAW (Phillips et al. 1991;Metten et al. 1998), see below] have also been useful. Finally, there are QTL data for human AD diagnoses, and for the low LR trait, and we touch upon the evidence for consistency in this area as well [for a more thorough comparison of the QTL data,
