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Chunk #29 — Results — Performance of PRSs in the Women’s Health Initiative dataset

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Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.
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For anthropometric traits, EA GWASs sample sizes ranged from 212-253K individuals. The pattern of results was similar for all anthropometric traits, in that optimal PRSs had SNPs selected according to EA GWAS, with weights according to the meta-analysis of the EA and the HCHS/SOL GWASs. Optimal SNP selection threshold varied, but were quite high (0.001-0.5).