Chunk #3 — Results — European ancestry GWAS: Substance-specific risk. — Problematic Alcohol Use.

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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

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ASSET analyses revealed 9 independent SNPs in 6 loci associated specifically with PAU (Supplemental Figure 3B; Supplemental Table 7 and 8). As expected8, the top signal was rs1229984 in ADH1B (p-value=4.11E-68). Gene-based enrichment analyses also implicated the alcohol dehydrogenase activity zinc dependent pathway (pbonferroni=0.035; Supplemental Table 9).