Chunk #2 — Results — European ancestry GWAS: Substance-specific risk.

Source

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

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To identify loci associated with only a single substance (i.e. not pleiotropic), we used ASSET24 (1-sided p < 5e-8). SNPs that were associated at GWS with only a single individual substance (PAU, PTU, CUD, or OUD) were considered substance-specific (e.g., CHRNA5 SNPs were only associated with PTU; Supplemental Figure 3B–E).