paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #25 — RESULTS — Rs9829896 Identified in the AA-specific GWAS and Replicated

Source
KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.
Embedded
yes

Text

To assess the degree to which rs9829896 association with drug abuse was a general effect or driven by abuse of a specific drug, we tested rs9829896 for association with each illicit drug category separately. As shown in Table 3, the rs9829896-C allele was significantly and consistently associated with reduced risk of abuse for all drug categories in the meta-analysis of UHS and GAIN AAs, with degree of significance varying largely by the number of cases available by illicit drug category and thus reflecting reduced statistical power (Table S13).