In EAs, the directionality was consistent with the AAs, the rs9829896-C allele being associated with reduced risk of drug abuse; however, the effect size was weaker, and the association was not significant in either the discovery or replication cohort (Table 2): meta-analysis P=0.12. The rs9829896-C allele occurred less frequently in AAs (frequency=12%) than in EAs (frequency=34%–36%). These allele frequencies are very similar to those observed in the 1000 Genomes AFR (10.2%) and EUR (35.5%) reference populations.
