the number of potential causal variants in a corresponding causal block. On the hover tips, users can find the median GWAS P-value of the credible set, and on clicking the block genomic position, they can navigate to the corresponding block view page. By searching for a gene name, considering that the average length of LD blocks is 1.6 Mb, the system will locate the target LD block in which the searched gene is present and display a block-wise causality plot (the number of potential causal variants in the LD block versus the median GWAS P-value of these variants) (Figure 2C). By searching for a chromosome region that is <10 Mb, users can investigate the causality of the most relevant LD block overlapped with the input region, and the results are similar to those when searching for a gene. By mapping the reported traits to MeSH, we established an ontology tree for users to browse the profile information of our collected GWASs, which further facilitates the navigation to traits of interest and the related causal block viewer (Supplementary Figure S8).
