A comment is needed regarding the relatively high rate of ASPD (34%) in mothers with AD. These mothers came from the BRFFS study and were members of a proband pair of alcohol dependent sisters. Because ascertainment through two AD sisters can be expected to increase the disease susceptibility within these families, comborbid conditions can be expected to be increased as well. Alcohol dependent women show elevated rates of ASPD relative to women without AD (Helzer et al., 1985). Because the offspring were at increased liability for disorders in their parents, it may be expected that the offspring were frequently diagnosed with CD.
