Although it is well-known that CD of youth and ASPD in adulthood are concomitants of alcohol and drug dependence, we would be remiss in focusing only on externalizing disorders in high-risk offspring. The adolescents in the present study were 4.4 times more likely to suffer from a depressive disorder than their low-risk cohorts. This suggests the need to identify these problems in vulnerable youth with an eye toward prevention of more serious problems including suicide.