Nine studies evaluated the association of stimulant medication and marijuana abuse or dependence, with ORs ranging from 0.39 to 4.87 (Figure 3). Seven of these studies found no association, whereas 2 studies27,32 reported that treatment with stimulant medication significantly reduced the risk of developing marijuana abuse or dependence. The random-effects model estimated comparable odds of marijuana abuse or dependence for children who did vs did not receive medication (OR, 0.97; 95% CI, 0.59−1.59; P =.87); however, significant heterogeneity was observed across the studies (Q = 15.68, P=.047).
