Here we present the results from the first GWAS of age at onset of AD. Survival analysis identified 38 SNPs showing genome-wide significance (p < 5.0 × 10−8) and 909 SNPs showing suggestive association (p < 5.0 × 10−5) with age at onset of AD. The genome-wide significant SNP rs2168784 was in strong LD with 33 imputed/genotyped SNPs spanning a 60 kb region on chromosome 3, from a long intergenic non-coding RNA (lincRNA) to 106 kb 3′ of the Sucrase Isomaltase (SI) gene (please see supplemental e Fig. 1 for regional plot for variants flanking rs2168784). The same SNPs also showed association with AD but with less significance than the age at onset analyses, this is most likely due to the fact that there are many people in this dataset who are young and have therefore not yet passed through the peak period of risk for developing AD. The chromosomal region identified in the current association analysis partially overlaps with the alcohol dependence linkage signal on chromosome 3 previously reported in a COGA dataset (Foroud et al., 2000b) from which
