Two intronic SNPs, rs35951 and rs35952 (MAF = 0.14, HR = 1.43, P = 1.11 × 10−8) in ADP-ribosylation factor like 15 (ARL15) gene on chromosome 5 and one intronic SNP, rs57083693 (MAF = 0.22, HR = 1.35, P = 4.32 × 10−8) in UTP20 small subunit (UTP20) gene on chromosome 12, were also associated with incidence of AD at genome-wide significance. The cumulative incidence plot showed that by the age of 20 years nearly 37% of subjects homozygous for the minor allele of rs35951 were diagnosed with AD, while only 17% of subjects homozygous for major allele developed AD (Fig. 3B). The CI plot for rs57083693 showed a dominant effect of the minor allele on the age at onset of AD (Fig. 3C). By age of 20 years nearly 25% carriers of minor allele of rs57083693 were diagnosed with AD, while only 19% subjects homozygous for major allele were diagnosed with AD at age 20.
