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Chunk #3 — Introduction

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Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.
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et al., 1999) in adulthood, which reported a heritability of 0.6. Furthermore, linkage studies have identified loci associated with SRE (Ehlers et al., 2010; Schuckit et al., 2001), and variants in GABRA2 were nominally associated with both subjective and objective measures of alcohol sensitivity in an Australian sample (Lind et al., 2008). A variety of gene sets are hypothesized to influence alcohol sensitivity (Schuckit, 2018), but in the absence of molecular genetic analyses, these remain speculative.