The current study aims to expand information available on genetic influences underlying initial sensitivity to alcohol. We conducted a meta-analysis of genome-wide association studies (GWAS) on SRE scores from two independent, population-based cohorts. While both samples are predominantly of European descent, one sample also included individuals of African (AFR) and American (AMR) descent. By elucidating the biological underpinnings of initial sensitivity to alcohol, we can improve existing models of mechanisms underlying risk of alcohol misuse, and potentially inform personalized intervention and prevention programming that might be used even before the first drink.
