(meta-analysis P = 5.44x10-8) than rs4878712 alone (meta-analysis P = 4.47x10-7), which may indicate a shared haplotype with a causal variant representing a single signal. Second, although different types of HIV exposure were present in both the discovery and replication cohorts, differences in the predominate modes of HIV exposure between the UHS IDUs and the all female WIHS cohort would tend to emphasize genetic factors that are common across modes of exposure and could have limited our ability to replicate findings. Another limitation is that the gene expression analyses in this study are limited by the publically available data. The Montgomery et al.[34] RNAseq data provided the strongest evidence of rs4878712 as an eQTL for FBXO10, particularly for exon 11. The MuTHER resource data[36] provided corroborating evidence of reduced FBXO10 expression associated with the rs4878712 G allele for an expression array probe located near exon 11. However, a more distal probe near exons 4/5 did not show such an association. Additionally, the available gene expression data are from subjects of European ancestry. Analysis of African American samples in the future would be of significant value. It will also be of value for future studies to move beyond the in vitro
