In addition to investigating the loss of nFGFR1 function, our experiments showed that overactive nFGFR1 also affects the neuro-ontogenic programs. Excessive nFGFR1 gene targeting was shown in schizophrenia NPCs during their differentiation29. Thus, an over-activation by nFGFR1 of neurodevelopment gene programs in subcortical NPCs could lead to their premature migration and differentiation observed in the subcortical regions of the schizophrenia organoids.
