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Chunk #66 — Discussion — Role of FGFR1

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Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1.
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Within the list of the nFGFR1-regulated genes (Supplementary Table 7), ∼75% were previously shown to bind to nFGFR1 in control and/or schizophrenia iPSC-derived differentiating NCCs29. Thus, the effects of transfected dominant negative and constitutively active nuclear forms of FGFR1 predominantly reflect direct gene control by the nuclear receptor.