Chunk #13 — METHODS — Data analysis — Post‐multivariate GWAS analyses — Mediation model

Source

Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.

Embedded

yes

Text

A follow‐up mediation model was examined in GenomicSEM using AUD and sensation seeking and alcohol consumption latent factor summary statistics. This model tested whether genetic influences underlying sensation seeking exert direct effects on AUD or whether this relation is mediated by effects on alcohol consumption, which in turn influence AUD (indirect path).