Multi‐marker Analysis of GenoMic Annotation (MAGMA, v1.08) 43 via FUMA (v1.3.7) 44 was used to conduct gene‐based association tests. SNPs were mapped to protein‐coding genes using Ensembl build 92. Chromatin interaction mapping was performed via Hi‐C‐coupled MAGMA (H‐MAGMA) 45 using MAGMA v1.10 and two Hi‐C datasets obtained from the Won Lab GitHub repository (https://github.com/thewonlab/H-MAGMA ): (1) cortical neurons from the dorsolateral prefrontal cortex (dlPFC) and (2) dopaminergic neurons from the midbrain (DA‐midbrain), including the ventral tegmental area and substantia nigra. H‐MAGMA extends MAGMA by incorporating long range chromatin interaction profiles (Hi‐C) to identify neurobiologically relevant SNP‐gene‐tissue associations for non‐coding (intergenic and intronic) SNPs. Significant MAGMA and H‐MAGMA genes were identified using Bonferroni‐corrected one‐sided P‐values adjusted for the number of genes tested.
