Although one polymorphic CNV component of size 1,691bp, (occuring as a hemizygous deletion in 77 AA subjects) was significant in our permutation analysis, further investigation showed this 1,691bp deletion is part of a larger section of polymorphic deletions on chr3p26.1 spanning approximately 20kb (6214264–6194430 = 19,834bp). There were 40 additional AA subjects carrying smaller hemizygous deletions upstream of this region, bringing the total number of hemizygous deletion carriers to 117. Among all 117 subjects with any estimated deletion in this region, the 77 subjects carrying larger deleted segments of 1,691bp showed significant association. This region is an intergenic region, which includes some microRNAs, and the nearest known gene is GRM7 (chr3: 6,877,927–7,758,217; Size: 880kb) which is approximately 600kb away from the most significant polymorphic CNV segment observed here.
