Table 4 shows the results of the SNPratio pathways analysis undertaken for the speed factor in the Brisbane and LBC1936 cohorts. Two pathways, focal adhesion and cell junction, were identified in both cohorts. Interestingly, the ALIGATOR results for the speed factor also showed an association with the regulation of focal adhesion formation category (p = .004). We searched these two pathways for SNPs that were nominally significant in both cohorts. No SNPs were identified that were exclusively tied to the cell junction pathway, that is, they were also linked with the focal adhesion pathway. There were twenty-seven of these (in five known genes: LAMB4, COL5A1, COL4A1, VTN, and LAMA1). Seventeen SNPs in six genes (MAPK10, ITGA2, PIK3R1, TLN2, PRKCA, and PARVB) were identified only in the focal adhesion pathway. This included one non-synonymous coding SNP (rs704) on chromosome 17 in the VTN gene. The two significant biological pathways identified in the Brisbane and LBC1936 cohorts were not significant in the smaller LBC1921: focal adhesion pathway, p = .85; cell junction pathway, p = .99. Nor were any of the nominally significant SNPs identified within these pathways replicated (p > .05).
