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Chunk #25 — 3. Discussion

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Whole genome association scan for genetic polymorphisms influencing information processing speed.
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This was the first genome-wide association scan of chronometric information processing speed measures with a number of SNPs showing suggestive association with various traits in both the adolescent and elderly cohorts. Some of these SNPs were in genes that appeared to be theoretically relevant to cognitive processing. Furthermore, a biological pathways analysis revealed SNPs in the cell junction and focal adhesion pathways to be overrepresented at a nominal significance level for the speed factor. Pathways analysis of the other traits showed that biological process pathways (sets of molecular events with a defined beginning and end) were overrepresented among the associations of pathways with multiple variables.