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Chunk #20 — Results — Gene and Gene-Set Analyses

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Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.
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Using FUMA, markers were mapped to 18,363 protein coding genes; none met genome-wide significance criteria (p<2.72×10−6). Complete results are available in Supplemental Table 1, while the top 10 genes are listed in Table 3. The FUMA pipeline also uses the complete distribution of SNP p-values to conduct a gene-set analysis (Nset=10,891) using MSigDB (Subramanian et al., 2005). Only one gene set had a corrected p-value of <0.05: regulation of intracellular steroid hormone receptor signaling pathway (corrected p=0.03). Complete results are available in Supplemental Table 2.