Twin pair correlations for AUD and remission (in twin pairs concordant for lifetime AUD), and ORs reflecting risk in one twin given the presence of AUD or remission in the other, are displayed in Table 3. The MZ correlation for AUD was more than twice the DZ correlation in female pairs but less than twice the DZ correlation in male pairs, raising the possibility of shared environmental in addition to genetic influences on AUD in males. In MZ female (MZF) pairs, twins of co-twins with an AUD had 3.8 times the risk of having an AUD themselves, relative to twins whose co-twins did not have an AUD; in DZF pairs, this increased risk was 1.6. The CIs for MZF and DZF twins did not overlap, suggesting a distinct difference by zygosity. This differentiation was not discernible in male (M) twins, where ORs for MZM and DZM pairs were more similar. Remission appeared to have familial influences in male pairs, with significant ORs in MZM twins showing increased chance of remission in twins of remitted co-twins, with a similar trend in
