where ORs for MZM and DZM pairs were more similar. Remission appeared to have familial influences in male pairs, with significant ORs in MZM twins showing increased chance of remission in twins of remitted co-twins, with a similar trend in DZM twins. By contrast, female and opposite-sex (OS) pairs showed little familial resemblance on remission. Significant negative correlations of co-twin remission and twin AUD in MZ twins indicated a decreased chance of remission among twins of co-twins with lifetime AUD.