Because of their ability to use the information inherent in LD, testing associations with haplotypes may be more powerful than with individual SNPs (Chapman and Wijsman, 1998; Chiano and Clayton, 1998; Johnson et al., 2001). We observed associations of block 1, haplotype 4 with subjective “High” effects of alcohol using an uncorrected p-value, and of block 2, haplotype 1, with “Positive” effects of alcohol. However, individual analyisis of SNPs that compose these haplotypes did not reveal significant associations with positive and stimulant effects of alcohol. More studies of the association of haplotypes in this region to AD are needed to validate our findings.
