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Chunk #11 — Methods

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Genome-wide scan for self-rating of the effects of alcohol in American Indians.
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yes

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Level of response to alcohol was estimated using a retrospective report instrument the Self-Rating of the Effects of Alcohol (SRE) measure. This instrument asks study participants to retrospectively estimate the number of standard drinks containing ethanol (e.g. the equivalence of 12 oz. of beer, 4 oz. of wine, and 1.5 oz. of 80 proof beverage) that were required for that person to experience four potential effects of the drug: (1) feeling any effects, (2) feeling dizzy/trouble talking, (3) trouble thinking/walking, and (4) falling asleep when you didn’t want to. The instrument also queries an individual to rate these reactions during different time points in a persons life including: (1) the FIRST FIVE TIMES or so that they ever drank, (2) during the most recent 3 months and (3) during the period of heaviest alcohol intake (see Schuckit et al., 1997a,b). The score is generated by counting up the number of drinks reported in each time period (FIRST FIVE, last 3 months, heaviest period) and dividing this score by the number of effects (any, dizzy, trouble thinking, falling asleep) endorsed. If