disorder and psychiatric disorder diagnoses according to Diagnostic and Statistical Manual (DSM-III-R) (American Psychiatric Association, 1987) criteria in the probands and their family members (American Psychiatric Association, 1987). The SSAGA is a semi-structured, poly-diagnostic psychiatric interview that has undergone both reliability and validity testing (Bucholz et al., 1994; Hesselbrock et al., 1999). It has been used in another Native American sample (Hesselbrock et al., 2000, 2003). Personnel from the Collaborative Study on the Genetics of Alcoholism (COGA) trained all interviewers. The SSAGA interview includes retrospective lifetime assessments of alcohol use, abuse, and dependence. A research psychiatrist/addiction specialist made all best final diagnoses.