fronto-occipital fasciculus, and hence that possibility that some of the voxels defined by the labelmaps were influenced by crossing fibers cannot be discounted. However, given the fact that average Mode was highly positive (>.6) in these fibers, combined with the fact that Mode is typically sub-zero in voxels severely influenced by fiber crossings (Ennis and Kindlmann, 2006) suggests that the majority of voxels defined by labelmaps were not significantly influenced by crossing fibers.