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Chunk #49 — 4. Discussion

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Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study.
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significant IHTT/DTI correlation, does not lie directly over the end-points of the visual CC fibers extracted from the DTI data. Notwithstanding recent developments in high-density electrode setups, however, the spatial resolution of standard, scalp-recorded EEG is typically no better than several centimeters (Srinivasan et al., 1998). Given this technical limitation, it was not feasible to predict a priori, on the basis of their spatial locations, which electrode pair would provide the most reliable measure of IHTT. In light of this, we instead investigated for IHTT/DTI correlations in a battery of four electrode pairs, and subsequently performed a conservative correction for multiple comparisons. That is, rather than an a priori selection based on their spatial locations, these four electrode pairs were selected a posteriori on the basis of the magnitude of their visual-evoked potentials. Finally, it should also be acknowledged that a number of longitudinal fasciculi pass close to the visual CC fibers, including the inferior longitudinal fasciculus and the inferior fronto-occipital fasciculus, and hence that possibility that some of the voxels defined by the labelmaps were influenced by crossing fibers cannot be discounted. However, given the fact that average Mode was highly positive (>.6) in these fibers, combined with the