A limitation of the present study relates to the fact the most of the schizophrenia patients had been taking antipsychotic medications for several years. This is problematic in light of research indicating that antipsychotic medications (both typical and atypical) can influence brain structure and function in and of themselves (Konopaske et al., 2008). It should be reiterated that the schizophrenia patients in the present study did not exhibit abnormalities in either their IHTTs or in the diffusion properties of their visual corpus fibers, and furthermore did not show a differential relationship between FA/Mode and IHTT to that of the HCs. Nevertheless, it would be highly advantageous if the results of the present study could be replicated in a sample of neuroleptic-naïve SZ patients. It should also be acknowledged that the P9/P10 electrode pair, which was the site of the one significant IHTT/DTI correlation, does not lie directly over the end-points of the visual CC fibers extracted from the DTI data. Notwithstanding recent developments in high-density electrode setups, however, the spatial resolution of standard, scalp-recorded EEG is typically no better than
