Table V lists the SNPs that were associated with any of the three traits at P<5E–04. Two statistically significant variants were identified in AAs. HTR2C (rs5988072) was associated with both DSM-IV CD (Padj = 8.89E–03, Bonferroni corrected) and the early-onset, heavy cocaine use, high comorbidity group (Group 5) (Padj = 4.99E–02, corrected by 1,000 permutation tests). A variant in CLOCK (rs11939815, Padj = 4.27E–02) was significantly associated with the heavy cocaine use, infrequent intravenous injection subtype (Group 4). Several genes contained nominally significant variants (P < 5E–04), but none were significant using permutation to adjust for multiple comparisons. In AAs, these included ALDH1A1 (rslll43429, P=3.35E–04), which was associated with DSM-IV CD; CLOCK (3 SNPs:rs3805155, P = 1.11 E–04; rsl3116194, P=2.11E–04; rs6850524, P=2.01E–04) and GLRA1 (rs991738, P=3.02E–04), which were associated with Group 4. In EAs, there was also a nominal association of a variant in SLC18A2 (rs363256, P = 2.27E–04) with this subtype. A variant in OXT (rs3761248, P = 3.04E–04) was nominally associated with Group 5 in AAs. Except for the findings related to HTR2C and ALDH1A1, the P values for all other variants listed in Table V were smaller for the derived subtypes than for DSM-IV CD.
