Removing the controls never exposed to cocaine from the genotyped subsample left 480 controls (187 AAs and 293 EAs). After data cleaning, there were 2,320 cases with a lifetime DSM-IV diagnosis of CD (1,291 AAs and 1,029 EAs). Of these, 779 AAs and 390 EAs were in Group 4 and 259 AAs and 436 EAs were in Group 5. Cases with data on all three phenotypes (DSM-IV CD, Groups 4 or 5) were tested separately for association against the same control samples, separately for AAs and EAs. SNPs were processed using the quality control steps for each individual case-control comparison, resulting in different numbers tested for association. Table IV describes the subjects and SNPs used in the association analyses.
